Hydroperoxy fatty acids HPODE

FIGURE 12.1 Activation of PPARa by dietary oxidized lipids is mediated by binding of hydroxy or hydroperoxy fatty acids, such as 9-HODE, 13-HODE, and 13-HPODE contained in the oxidized lipids to the PPARa protein which subsequently forms a complex with RXR. The PPARa/RXR complex binds to specific DNA sequences, called PPRE, present in and around the promoter of PPAR target genes, and, thereby, stimulates their transcription. PPARa can also negatively regulate transcription of genes, which are under the control of stress-sensitive transcription factors such as NF-kB and encode proteins involved in the stress and inflammation response. This is the molecular basis for the well-documented antiinflammatory effects of PPARa. 

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