Hydrolytic degradation polymers

J.A. Tamada, R. Langer, Erosion kinetics of hydrolytically degradable polymers, Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 552-556. 

Several excellent reviews have recently been published that describe the broad field of degradable biomedical polymers [9,10]. Well-known hydrolytically degradable polymers developed or being developed for biomedical used include homo- and copolymers of polyamides (usually derived from amino adds), polyesters, polyanhydrides, poly(ortho ester)s, poly(anfido amines), and poly(P-amino esters). This chapter is focused on polyacetals, which... 

Hydrolytically degradable polymer a degradable polymer in which the degradation results from hydrolysis. 

Stridsberg, K. and Albertsson, A.-C. (2000) Changes in chemictil and thermal properties of the tri-block copolymer poly(L-lactide-b-l,5-dioxepan-2-one-b-L-lactide) during hydrolytic degradation. Polymer, 41, 7321-7330. 

Poly(beta-amino esters) are cationic, hydrolytically degradable polymers that can be produced as polymeric NPs for gene delivery. Green et al. [71] developed small ( 200 nm), positively charged ( 10 mV), polymeric NPs by the self assembly of poly(beta-amino esters) and DNA. These NPs had four times greater gene delivery efficacy than those observed for Lipofectamine 2000 in human embryonic stem (ES) cells. These materials exhibited minimal toxicity and did not adversely affect the colony morphology or cause nonspecific differentiation of the ES cells. 

Andersson, S.R., Hakkarainen, M., Albertsson, A.-C., 2013. Stereocomplexation between PLA-fike substituted oligomers and the influence on the hydrolytic degradation. Polymer 54, 4105-4111. 

Tamada, J.A., Langer, R., 1993. Erosion kinetics of hydrolytically degradable polymers. Proceedings of the National Academy of Sciences of the United States of America 90, 552-556. 

K. Paakinaho et al., Melt Spinning of Poly (L/D) Lactide 96/4 Effects of Molecular Weight and Melt Processing on Hydrolytic Degradation, Polym. Degrad. Stab., 94, 438-442 (2009)... 

A review is presented of the use of degradable polymers for use in controlled drug delivery. Emphasis is given to the preparation, applications, biocompatibility, and stability of microspheres from hydrolytically degradable polymers. 320 refs. 

K. Paakinaho, V. Ella, S. Syijala, M. Kellomaki, Melt spinning of poly(l/d)lactide 96/4 effects of molecular weight and melt processing on hydrolytic degradation. Polym. Degrad. Stab. 94(3), 438 42 (2009)... 

Paul MA, Delcourt C, Alexandre M, Degee P, Monteverde F, Dubois P. Polylactide/ montmorillonite composites study of the hydrolytic degradation. Polymer Degradation and Stability 2005 87 535-42. 

---