Hydrolysis influencing factors enzymatic

An examination of some of the factors influencing the chemical and enzymatic hydrolysis of nicotinic acid esters was undertaken [45-48]. Twenty-five esters of nicotinic acid were prepared whose pro-moiety was a simple alkyl (unbranched, sec-, or /er/-alkyl), a chloroalkyl, a hydroxyalkyl, an alkoxyalkyl, a carbamoylmethyl, an aminoalkyl, a cycloalkyl, an arylalkyl, or an aryl group (Table 8.5). 

The pharmacokinetic implications of these findings are not straightforward. One important factor that must also be considered is hepatic extraction, which is higher for lovastatin than for its hydroxy acid metabolite [188], Some lactones are useful prodrugs of HMG-CoA reductase inhibitors due to this organ selectivity coupled with the efficiency of enzymatic hydrolysis. However, other factors may also influence the therapeutic response, in particular the extent and rate of metabolic reactions that compete with or follow hydrolysis, e.g., cytochrome P450 catalyzed oxidations, /3-oxidation, and tau-... 

Biodegradable polymers used in the field of controlled drug delivery are typically degraded by hydrolysis [38]. In addition, some biomedical polymers are enzymatically degradable [35,39]. Many factors are known to influence the bio-... 

Many factors influence the reactivity and digestibility of the cellulose fractions of lignocellulose materials. These factors include Hgnin and hemicellulose content, crystalhnity of cellulose, and the porosity of the biomass materials. Pretreatment of Hgnocellulosic materials prior to utiHzation is a necessary element in biomass-to-ethanol conversion processes. The objective of the pretreatment is to render biomass materials more accessible to either chemical or enzymatic hydrolysis for efficient product generation. The goals of the pretreatment are ... 

Tiwari, M., Guha, S., Harendranath, C., Tripathi, S., 2006. Influence of extrinsic factors on granulation in UASB reactor. Applied Microbiology and Biotechnology 71 (2), 145—154. Ufkun Kiran, E., Trzcinski, A.P., Liu, Y., 2015. Enhancing the hydrolysis and methane production potential of mixed food waste by an effective enzymatic pretreatment. Bioresource Technology 183, 47—52. 

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