Platelet activating factor hydrolase

L. W. Tjoelker, C. Eberhardt, J. Unger, H. Letrong, G. A. Zimmerman, T. M. McIntyre, D. M. Stafforini, S. M. Prescott, P. W. Gray, Plasma Platelet-Activating Factor Acetyl-hydrolase Is a Secreted Phospholipase A2 with a Catalytic Triad ,./. Biol. Chem. 1995, 270, 25481-25487. 

Marathe, G.K., G.A. Zimmerman, and T.M. McIntyre Platelet-activating factor acetylhy-drolase, and not paraoxonase-1, is the oxidized phospholipid hydrolase of high density lipoprotein particles. J. Biol. Chem. 278 (2003) 3937-A7. 

Kusano K, Seko T, Tanaka S, et al. (1996). Purfication and characterization of Rhesus monkey liver amido hydrolases and their roles in the metabolic polymorphism for E6123, a platelet-activating factor receptor antagonist. Drug Metabol. Dispos. 24 1186-1191. 

Other enzymes are involved in biodegradation of OPs some are hydrolases such as prolidases, senescence marker protein (SMP), and platelet-activating factor (PAF-AH) others are oxidases, such as cytochromes... 

A large and diverse group of proteins, including enzymes, cytoskeleton, contractile proteins, and receptors, have been shown to be modified by calpains. Thus, a number of enzymes such as tyrosine hydrolase, tryptophan hydrolase, transglutaminase, protein kinase C, and membrane Ca2+-ATPase are activated by calpain proteolysis [38]. Several receptor proteins, in particular receptors for steroid hormones, growth factors, and adrenaline, are modulated by calpains, which participate also in platelet activation, cell fusion, and mitosis [39], Although the physiological roles of calpains continue to be un-... 

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