Senescence marker protein

Plasma retinal-binding protein precursor Senescence marker protein-30... 

Kondo, Y., Ishigami, A., Kuho, S., Handa, S., Gomi, K., Hirokawa, K., Kajiyama, N., Chiba, T., Shimokado, K., Maruyama, N. (2004). Senescence marker protein-30 is a unique enzyme that hydrolyzes diisopropyl phosphorofluoridate in the liver. FEBS Lett. 570 57-62. 

The human senescence marker protein-30 (SMP30 or regucalcin, primary Swiss-Prot accession No. 

Choi, M.S., Saxena, A., Chilukuri, N., 2010. A strategy for the production of soluble human senescence marker protein-30 in Esckeria coli. Biochem. Biophys. Res. Commun. 393, 509-513. 

In the literature, there are articles reporting an important role of senescence marker protein-30 (SM-30) in hydrolysis of DFP and similar substrates (Kondo et al., 2004 diTargiani et al., 2010). SM-30 protein was given the code EC 3.1.8.2, which was previously assigned to DFPase. After checking all available data, it appears... 

Other enzymes are involved in biodegradation of OPs some are hydrolases such as prolidases, senescence marker protein (SMP), and platelet-activating factor (PAF-AH) others are oxidases, such as cytochromes... 

Belinskaya, T, Pattabiraman, N., diTargiani, R., et al, 2012. Differences in amino acid residues in the binding pockets dictate substrate specificities of mouse senescence marker protein-30, human paraoxonase 1, and squid diisopropyl-fluorophosphatase. Biochim. Biophys. Acta 1824, 701-710. 

Chakrabort S., Bahnson, B.J., 2010. Crystal structure of human senescence marker protein 30 insights linking structural, enzymatic, and physiological functions. Biochemistry 49, 3436-3444. 

Kondo, Y., Ishigami, A., Kubo, S., et al, 2004. Senescence marker protein-30 is a unique enzyme that hydrolyzes diisopropyl phosphorofluoridate in the... 

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