Hydrogen peroxide, addition platinum complexes

The dimer (3) has been reported to react with calf thymus DNA [159]. Extended X-ray absorption fine structure (EXAFS) analysis of the platinated DNA revealed that the two platinum ions remained close to one another in the initially formed adduct (1 day incubation), but that over an extended period of time (8 day incubation) they separate from each other. In addition, compound (3) as well as its EtNH2 and Pr NH2 analogues, but not the hydrogen peroxide oxidation products of the complexes, are known to bind to and unwind supercoiled PM2-DNA (Peritz and Dabrowiak, unpublished data). 

Fig. 1. This illustrates the zero-order reaction kinetics of the oxidation of ascorbic acid by horseradish peroxidase-hydrogen peroxide complex. The disappearance of hydrogen peroxide upon the addition of 3 mM ascorbic acid is recorded by means of the platinum microelectrode (Expt. 574e).

Hydrosilylations of fluorine-containing alkenes are free radical reactions initiated by UV light or organic peroxides The direction of addition is the same as with fluonnated alkyl halides However, the reaction between hydrosilanes and fluorine-containing olefins catalyzed by platinum group metal complexes may result in bidirectional addition and/or formation of a vinylic silane, the latter by de hydrogenative silylation[/] The natures of both the silane and the catalyst affect the outcome of the reaction[7] A random selection of some typical new reactions of silanes are shown in Table 1 [1, 2, 3 4]... 

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