Hydrogen/deuterium exchange experiment

Protonated methanes and their homologues and derivatives are experimentally indicated in superacidic chemistry by hydrogen-deuterium exchange experiments, as well as by core electron (ESCA) spectroscopy of their frozen matrixes. Some of their derivatives could even be isolated as crystalline compounds. In recent years, Schmidbaur has pre-... 

This section is not complete without mentioning the hydrogen-deuterium exchange experiment by Doehring and Hoffmann (12), which indicated an enhanced acidity of the hydrogens in a tetramethylstibonium salt. In the corresponding equilibrium, stibonium ylides play the role of strong bases ... 

Hydrogen-deuterium exchange experiments have been used extensively to study both structural parameters and dynamic and mechanistic aspects. They are utilized in conjunction with both NMR and IR studies. Mass spectrometry, with its high sensitivity and resolution, is ideally suited for isotopic exchange studies. 

Figure 20 Example of hydrogen-deuterium exchange experiment monitored by HSQC. A portion of the HSQC spectrum of...

Hydrogen-deuterium exchange experiments were carried out in the high-vacuum apparatus used for the resistivity-adsorption measurements. 

Kazazic, S., Zhang, H.M., Schaub, T.M., et al. (2010) Automated data reduction for hydrogen/deuterium exchange experiments, enabled by high-resolution Fourier transform ion cyclotron resonance mass spectrometry. JAm Soc Mass Spectrom, 21 (4), 550-558. 

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