Hydrogen bromide precautions

Place 50 g. (57 ml.) of dry A.R. benzene and 0 5 ml. of dry p rridine (1) (dried over potassium hydroxide pellets) in a 500 ml. round-bottomed flask. Attach a reflux condenser to the flask and an inverted funnel (just dipping into some water in a beaker) to the top of the condenser (Fig. II, 13, 8, b). Partially immerse the flask in a bath of cold water, supported upon a tripod and gauze. Carefully pour 125 g, (40 ml.) of bromine (for precautions to be taken with bromine, see Section 111,35, Note 1) through a condenser and immediately insert the absorption device into the upper end of the condenser. A vigorous reaction soon occurs and hydrogen bromide is evolved which is absorbed by the water in the beaker when the reaction slackens, warm the bath to 25-30° for... 

Hydrazoic acid reaction with cyclobu-tanecarboxyhc acid, 47, 28 Hydrogenation of t butylazidoacetate to glycme ( butyl ester, 46,47 Hydrogen bromide 46, 43 reaction with y butyrolactone, 46, 43 Hydrogen fluoride anhydrous, precautions in use of, 46, 3 in preparation of mtromum tetra-fluoroborate 47, 57 reaction with benzoyl chloride, 46,4 with boron tnfluonde in conversion of p cymene to m cymene, 47, 40 in bromofluorination of 1 heptene, 46, 11... 

The less volatile residues should be quite free of bromosilane. However, as a precaution, nitrogen is admitted into the reaction tube, the adapter is removed, and the contents of the tube are poured over pulverized Dry Ice contained in a sink in a hood. Water is then allowed to run over the Dry Ice. The recovered hydrogen bromide can be stored at room temperature after first being condensed at —196° into a 150-ml. stainless-steel cylinder fitted with a stainless-steel needle valve. It is important to... 

Toxicology LD50 (oral, rat) > 5000 mg/kg, (skin, rabbit) > 2000 mg/kg contact may result in skin, eye irritation nonmutagenic Precaution Incompat. with strong alkalis, may cause hydrolysis and release of bromine treat as burning oil Hazardous Decomp. Prods. Hydrogen bromide, CO,... 

Precaution Hazardous decomp. > 70 C avoid strong bases Hazardous Decomp. Prods. Above 160 C, bromide and hydrogen bromide fumes may be released heated to decomp., emits very toxic fumes of Br and NO,... 

Properties Off-wh. cryst. powd. sol. in ketone, chlorinated and aromatic soivs. m.w. 641.73 dens. 2.36 m.p. 173-177 C Toxicology LD50 (oral, rat) > 10,000 mg/kg, (dermal, rabbit) > 10,000 mg/kg irritating to eyes, skin, respiratory system Precaution Incompat. with strong oxidizers Hazardous Decomp, Prods. CO, CO hydrogen bromide, irritating and toxic fumes and gases... 

Precaution DOT corrosive liq. incompat. with strong oxidizers, strong bases avoid high temps., contamination by water Hazardous Decomp. Prods. Heated to decomp., may release poisonous fumes of hydrogen bromide and bromine... 

Toxicology ACGIH TLV/CL 1 ppm poison corrosive irritating to skin, eyes, mucous membranes TSCA listed Precaution Dangerous can explode on heating reacts violently with water dec. by water to form hydrogen bromide gas incompat. with K, Na... 

Precaution DOT Flamm. liq. can react with oxidizing agents and sodium bromobutane Hazardous Decomp. Prods. Heated to decomp., emits toxic fumes of CO, CO2, hydrogen bromide gas high vapor cones, may be anesthetic... 

Environmental May be toxic to aquatic organisms do not release into waters Precaution Incompat. with strong oxidizers Hazardous Decomp. Prods. Hydrogen bromide and/or bromine, COx may emit toxic/irritating fumes underfire conditions Storage Store in cool, dry, well-ventilated area away from incompat. materials keep container tightly closed... 

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