Bioresponsive hydrogel

The goal of this research is to develop a new class of bioresponsive materials that undergo rapid, large-magnitude, volume-phase transitions in response to specific biological stimuli. Our approach to these materials is based on two fundamental aspects of hydrogels (1) hydrogel solvation/desolvation thermodynamics can be perturbed... and... 

Fig. 27 Cross-sectional view of a bioresponsive insulin delivery system, a feedback-regulated drug delivery system, showing the glucose oxidase-entrapped hydrogel membrane constructed from amine-containing hydrophilic pol5mier. The mechanism of insulin release, in response to the influx of glucose, is also illustrated. (From Ref. l)...

Ulijn RE, Bibi N, Jayawama V, Thornton PD, Todd SJ, Mart RJ, Smith AM, Gough JE (2007) Bioresponsive hydrogels. Mater Today 10(4) 40 8 Urban GA (2006) BioMEMS. In Senturia SD (ed) Microsystems, vol.l6. Springer, Dordrecht, NL... 

Kim J, Nayak S, Lyon LA (2005a) Bioresponsive hydrogel microlenses. J Am Chem Soc 127 9588-9592... 

All active principles introduced earlier are per se unidirectional. However, the implementation of feedback loops allows for bioresponsive hydrogels that exhibit a true self-regulation capacity. These next-generation systems can adopt magnitude and direction of the response to the respective stimulus like the concentration of a particular biomolecule in the local enviromnent. This... 

FIGURE 6.28 Different types of bioresponsive hydrogels that change properties in response to (I) small molecules via receptor/ligand interactions (II) (ceU-secreted) enzymes via cleavable linkers and (III) small molecules that are convated by immobilized enzymes. The macroscopic response (sweUing/coUapse of the hydrogel) is shown. Source Ulijn et al. [113]. Reproduced with permission of Elsevier. 

Bioresponsive hydrogels can be employed to implement a self-regulating system for controlled release of insulin in response to an environmental glucose concentration. Toward this goal, Podual et al. [116] prepared a series... 

Bahney, C.S., Lujan, T.J., Hsu, C.W., Bottlang, M., West, J.L., Johnstone, B., 2011. Visible light photoinitiation of mesenchymal stem ceU-laden bioresponsive hydrogels. Eur. Cell Mater. 22, 43—55 discussion 55. 

Kim J, Singh N, Lyon LA (2007) Displacement-induced switching rates of bioresponsive hydrogel microlenses. Chem Mater 19 2527-2532... 

Wang, D. A., Williams, C. G., Yang, F. et al. 2005. Bioresponsive phosphoester hydrogels for bone tissue engineering. Tissue Eng 11 201-13. 

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