Hydrocodone dosage

Dosages and routes of administration Hydrocodone is used orally in doses of 5-10 mg. 

This type of CrDDS is exemplified by the development of Pennkinetic system (by Pennwalt Pharmaceuticals), which permits the formulation of oral liquid-type dosage forms with sustained release of a combination of hydrocodone and chlorpheniramine (Tussionex ). - ]... 

Fatmi, A.A. Williams, G.V Simultaneous determination of acetaminophen and hydrocodone bitartrate in solid dosage forms by HPLC. J.Liq.Chromatogr., 1987,10, 2461-2472 [simultaneoushydrocodone formulations]... 

Alvi, S.U. Castro, F. A stability-indicating simultaneous analysis of acetaminophen and hydrocodone bitartrate in tablets formulation by HPLC. J.Liq.Chromatogr., 1987, 10, 3413-3426 [stability-indicating simultaneous impurities, acetaminophen, codeine, hydromorphone tablets column temp 30] Fatmi, A.A. Williams, G.V. Simultaneous determination of acetaminophen and hydrocodone bitartrate in solid dosage forms by HPLC. J.Liq.Chromatogr., 1987, 10, 2461—2472... 

Psychiatric A 60-year-old woman developed a psychosis after taking dextromethorphan at more than the recommended over-the-counter dosage, propoxyphene, and hydrocodone [71 ]. She developed religious and paranoid delusions, olfactory and visual hallucinations, and agitation. Propoxyphene may have slowed the metabolism of dextromethorphan, resulting in intoxication. 

For the symptomatic relief of moderate to moderately severe pain, hydrocodone should be administered in the smallest dose as infrequently as possible to achieve the desired treatment effect and minimize the development of tolerance and dependence. The usual adult dosage is 5 to 10 mg PO every 4 to 6 hours as necessary, with manufacturer recommendations on maximum daily total doses of 60 mg when combined with acetominophen and 37.5 mg when combined with ibuprofen. Unlike when used as an antitussive, where the recommended dose for children 6 to 12 years of age is 2.5 mg PO every 4 to 6 hours as necessary with a daily maximum of 15 mg, there is no consensus pediatric recommendation for the use of hydrocodone bitartrate as an analgesic agent. Additionally, in both cases, there are no data on the efficacy and safety of its use in children under 6 years of age. However, some authors and clinicians recommend an analgesic pediatric starting dose, based on the hydrocodone component of various preparations, of 0.1 mg/kg every 4 to 6 hours as needed, similar to the pediatric dose of oxycodone. 

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