Pennkinetic system

This type of CrDDS is exemplified by the development of Pennkinetic system (by Pennwalt Pharmaceuticals), which permits the formulation of oral liquid-type dosage forms with sustained release of a combination of hydrocodone and chlorpheniramine (Tussionex ). - ]... 

Pennkinetic System Skye Pharma AG, Muttenz, Switzerland The system combines CR principles of ion exchange with membrane diffusion. The system is made up of an ion-exchange polymer-drug complex as a core material, which is subsequently coated with ethylcellulose to form a water insoluble but permeable coating. Release rates are relatively constant and unaffected by variable conditions of the GI tract. The system can be formulated in capsule form as well as suspensions. Delsym (Dextromethorphan), Corsym (Chlorpheniramine) and Cold Factor 12 (Phenylpropanolamine). 

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