Irbesartan Hydrochlorothiazide

Empirin, Equagesic, Excedrin, Fiorinal, Gelprin, Halfprin, Avalide hydrochlorothiazide, irbesartan... 

Huang XH, Qiu FR, Xie HT, Li J. 2005. Pharmacokinetic and pharmacodynamic interaction between irbesartan and hydrochlorothiazide in renal hypertensive dogs. J Cardiovasc Pharmacol 46 863-869. 

Note Aldactazide is spironolactone and hydrochlorothiazide Aldoril is methyldopa and hydrochlorothiazide Avalide is irbesartan and hydrochlorothiazide Capozide is captopril and hydrochlorothiazide Dyazide is triamterene and hydrochlorothiazide Maxzide is triamterene and hydrochlorothiazide Moduretic is amiloride and hydrochlorothiazide Prinizide is lisinopril and hydrochlorothiazide... 

Angiotensin-II-receptor antagonists (ARBs) are approved for the treatment of hypertension. In addition, irbesartan and losartan are approved for diabetic nephropathy, losar-tan is approved for stroke prophylaxis, and valsartan is approved for heart failure patients who are intolerant of angiotensin-converting enzyme (ACE) inhibitors. The efficacy of ARBs in lowering blood pressure (BP) is comparable with that of other established antihypertensive drugs, with an adverse-effect profile similar to that of placebo. ARBs also are available as fixed-dose combinations with hydrochlorothiazide. 

Symptomatic hypotension may occur when an angiotensin II receptor antagonist is started in patients taking high-dose diuretics. Potassium levels may be either increased, decreased or not affected. No clinically relevant pharmacokinetic interactions appear to occur between candesartan, eprosartan, irbesartan, losartan, telmisartan or valsartan and hydrochlorothiazide, although the bioavailability of hydrochlorothiazide may be modestly reduced. Similarly, there is no clinically significant pharmacokinetic interaction between valsartan and furosemide. 

In a randomised, crossover study in 13 healthy subjects, telmisartan 160 mg daily was given with hydrochlorothiazide 25 mg daily for 7 days. There was no difference in AUC and maximum plasma concentrations of either drug compared with when they were given alone. Similarly, no pharmacokinetic interactions were found between irbesartan and hydrochlorothiazide. ... 

Drug product recall of 60 million tablets of the blood pressure medication Avalide, a combination of two anti-hypertensives, hydrochlorothiazide and irbesartan. Concerns were over possible variability in the amounts of the less soluble polymorph of irbesartan, which may result in slower dissolution. 

Urinary tract Severe acute tubulointerstitial nephritis with tubular atrophy and minimal fibrosis has been reported in a 69-year-old Caucasian man who was taking irbesartan, hydrochlorothiazide, ezetimibe, and omeprazole [64 ]. Withdrawal of irbesartan and hydrochlorothiazide had no effect. Omeprazole was withdrawn, and there was dramatic improvement. 

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