2- hydro-2-oxo

An interesting example of the coordination polymerisation of a phosphacyclic monomer is represented by the polymerisation of oxyphosphonoyloxytrimethy-lene (2-hydro-2-oxo-l,3,2-dioxaphosphorinane) in the presence of triisobutyla-luminium as the catalyst [181,182], This polymerisation, carried out at a temperature of 25 °C, produced, in relatively high yield, poly(oxyphosphonoy-loxytrimethylene) which appeared to be a high molecular weight polymer (Table 9.2). 

Enthalpies of activation of both reactions, proceeding with rate constants kiand k2 are nearly the same for 2-methoxy substituted monomer. Ratio ki/k2 = 3 was calculated in 40° and 100°. 2-Neopenthoxy substituted monomer does not participate in Arbuzov type transfer and the rate constant ki is approximately 40 times lower than for 2-methoxy derivative. When substituent was changed to t-buthoxy group decomposition of intermediate salt into isobutylene, 2-hydro-2-oxo-l,3,2-dioxaphospholane and 2-methyl-2-oxo-l,3,2-dioxaphospholane was observed. 

The transesterification of H-phosphonate diesters with 1,3 propanediol is accompanied however by the formation of 2-hydro-2-oxo-l,3,2-dioxaphosphorinane in 75 to 85% yield [28], This compound results from the nucleophilic attack of the terminal hydroxyl group of the monotransesterificated product at the phosphoras atom. 

It was found that the transesterification of dimethyl H-phosphonate with 1,2-propane-diol yields 4-methyl-2-hydro-2-oxo-l,3,2-dioxaphospholane [56]. Obviously, the first stage of the reaction furnished methyl-2-hydroxypropyl H-phosphonate. Subsequent intramolecular transesterification of the methyl-2-hydroxypropyl phosphonate yielded 4-methyl-2-hydro-2-oxo-l,3,2-dioxaphospholane. The specific reactivity of these esters of H-phosphonic acid is determined by the presence of a P-hydroxyl gronp. The role of the P-hydroxyl gronp may be regarded as an intramolecular catalysis. The reactivity enhancement of P-hydroxylethyl esters of H-phosphonic acid probably can be explained through hydrogen bonding, which favors the intramolecular transesterification reaction. 

In the P H NMR spectrum of 4-methyl-2-hydro-2-oxo-l,3,2-dioxaphospholane measured immediately after distillation, there are two signals at 5=23.92 ppm and... 

Polymerization of the 2-hydro-2-oxo-l,3,2-dioxaphosphorinane, initiated anionically or with aluminum alkyls, resulted in poly(alkylene H-phosphonate)s [291],... 

The reversible anionic polymerization of 2-hydro-2-oxo-1,3,2-dioxaphosphorinane (22) in bulk or in CH2CI2 solution, initiated by EtONa, Bu OK, Bu Li, or (Bu )3Al at 25-45 °C led to the high molar mass linear polymer with up to 10. The... 

Durch Kondensation von 2-Phenyl-2-oxo-acethydroximsaure-chlorid und Benzamidin-Hydro-chlorid erhalt man 2,4(5)-Diphenyl-5(4)-nitroso-imidazol (s.Bd. X/l, S. 1071). 2,2-Dicyan-3-phenyl-oxiran reagiert mil Amidinen unter Abspaltung von Benzaldehyd zu 4-Amino-5-cyan-imidazol115. Ein Beispiel fur diese Reaktion ist die U msetzung mit N-Phenyl -benzamidin zu 4-Amino-5-cyan-1,2-diphenyl-imidazol (80%) ... 

In Gegenwart von 2,3-Dimethyl-buten-(2) bildefc 2-Oxo -1, 2-di hydro-chin olin neben 90% des Dimeren Vila noch 2-Oxo-9,9,10,10-tetramethyl-(benzo-3-aza-bicyclo[4.2.0] octen-(4)y (VIII 9,4% d.Th.)3 ... 

Sulfacytine, 4-Amino-N-lI-ethyl-I,2-dihydro-2-oxo 4-pyrimidinyl)benzenesulfonamide N - l-ethyl-l,2-di-hydro-2-oxo-4-pyrimidinyl)sulfanilamide 1 -ethyl -/V-sulfa -nilylcytosine N-sulfanilyl-l-ethylcytosine 0 636 Reno -quid. CiiH.jNjO.S mol wt 294.34. C 48.97%, H 4.79%, N 19.04%, O 16.31%, S 10.90%. Prepn Netb, pat. Appl. 

CAS 4991-65-5 EINECS/ELINCS 225-653-0 Synonyms 1,3-Benzoxathiol-2-one, 6-hydroxy- 6-Hydro-2-oxo-1,3-benzoxathiole 6-Hydroxy-1,3-benzoxathiol-2-one... 

Butanamide, N-(2,3-di-hydro-2-oxo-lH-benzimi-dazol-5-yl)-3-oxo-2-[[2-(tri-fluoromethyl)phenyl]azo]-/ C]8H]4F N503... 

In a further synthesis, Gut ° used the cyclization of the thiosemi-carbazone of glyoxylic acid (56) the 2-thioxo-5-oxo-2,3,4,6-tetra-hydro-l,2,4-triazine (57) formed was converted to 6-azauracil by applying aqueous solution of chloroacetic acid. (This reaction will be discussed later, e.g.. Section II,B,4,b.) The same procedure was used... 

D/chloro-5-Cyclohexyl-2-Oxo-2,3-D/hydro 1 H-Benzo(fj-Diazepine-1,4 fa) Process Using Sodium Hypochlorite — 40 ml of a solution of sodium hypochlorite of 14.5 British chloro-metric degrees are added to a suspension of 5.4 grams of 7 chloro-5 cyclohexyl-2 oxo-2,3-dihydro 1 H-benzo(f)diazepine-1,4 in BO ml of methylene chloride. The mixture is stirred at room temperature for 15 minutes the solid dissolves rapidly. The organic iayer is decanted, washed with water, dried over anhydrous Sodium sulfate and the solvent evaporated under reduced pressure without exceeding a temperature of 30 C. The residue is taken up in a little diisopropyl ether and the crystals which form are dried. They are recrystallized as rapidly as possible from ethyl acetate. Colorless crystals are obtained (3.9 grams yield, B5%) MP < = 163°C, with decomposition. 

Die Schiff schen Basen aus chiralen 1-Amino-1-phenyl-alkanen und 2-Oxo-alkansau-re-benzylestern lassen sich in situ mit Natriumboranat in THF zu den optisch aktiven N-Arylalkyl-aminosaure-benzylestern reduzieren, die durch katalytische Hydro-genolyse chirale Aminosauren ergeben2. 

Chlor-2,3-dihydroxy-5-aryl- 6/2 7-Chlor-2,3-dihydroxy-5-(2-chlor-pheny[)- 612 7-Chlor-2-hydroxy-5-(2-chlor-phenyl)- 612 7-Chlor-2-oxo-5-aryl-l,2,4,5-tetrahydro- 612 7-Chlor-2-oxo-5-(2-chlor-phenyl)-1.2,4,5-tctra-hydro- 612... 

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