Hydralazine predisposing factors

What are the predisposing factors identified in human patients that are important in the immune-media ted adverse effect lupus erythematosus caused by the drug hydralazine ... [Pg.401]

The predisposing factors for susceptibility to hydralazine-induced lupus identified in humans are (a) dose, (b) duration of therapy, (c) the ace ty la tor phenotype, (d) HLA (tissue) type, and (e) gender. [Pg.434]

Hydralazine. Vasodilator drug which causes systemic lupus erythematosus in a significant proportion of patients. Several predisposing factors have been identified dose (>25 mg) duration of therapy (mean 18 months) acetylator phenotype (slow) HLA type (DR4) gender (females males, 4 1). Antinuclear antibodies and antihydralazine antibodies detected in serum. Causes a Type III immune reaction. Mechanism is unclear but may involve reaction of parent drug or metabolite with protein. Interference with the complement system and interaction with nucleic acids also occur. Metabolism also may be mediated by myeloperoxidase in activated neutrophils. [Pg.665]

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