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HYBRIDIZATION WITH NUCLEIC ACID PROBES phosphate

The interactions of nucleic acid materials with Ln have been largely studied through their luminescent properties. The known affinity of Ln " cations for the phosphate moiety has led to many investigations of the Ln interactions with nucleotides, covered in some detail by Evans [1]. The interaction of Ln with nucleic acids has been used to probe perturbations in the integrity of nucleic acid strands and as an assay of nucleic acid hybridization. Balcarova and Brabec [45] showed that the interaction of Tb with double-stranded DNA can be used to monitor guanine bases present in distorted double-stranded regions of DNA. The enhancement of distortions in double-stranded DNA appears to be restricted to certain modifiers of nucleic acid as there is no... [Pg.356]

See other pages where HYBRIDIZATION WITH NUCLEIC ACID PROBES phosphate is mentioned: [Pg.206]    [Pg.210]    [Pg.130]    [Pg.173]    [Pg.232]    [Pg.15]    [Pg.549]    [Pg.254]    [Pg.33]    [Pg.140]    [Pg.741]    [Pg.130]    [Pg.56]    [Pg.114]    [Pg.163]    [Pg.456]    [Pg.270]    [Pg.273]    [Pg.81]    [Pg.411]   
See also in sourсe #XX -- [ Pg.232 ]



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Nucleic acid hybridization

Nucleic acid probes

Phosphate acid

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