Hybrid One-Pot Glycosylation

Besides the PMB and TBS moieties, other acid-labile protecting groups have been utilized in the one-pot assembly of oligosaccharides. These include benzylidene by Boons [111] and the trityl group by Li and coworkers in the synthesis of flaccidoside II, a bioactive component of Chinese traditional medicine [57], 

SCHEME 6.36 Mong s one-pot synthesis of trisaccharide 180 through combination of selective activation and armed-disarmed approach. 

SCHEME 6.37 Takahashi s one-pot synthesis of the glycosyl amino acid 187 by combining selective activation and regioselective glycosylation. 

We would like to thank the general financial supports from the National Science Foundation (CHE 1111550) and the National Institute of General Medical Sciences, NIH (R01GM072667) toward our work. 

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