Hybrid EB-TOF Instruments

FIGURE 9.17 SIMION representation of the broad energy-focusing reflectron designed by Enke et ai. (Reprinted with permission from reference 10). 

Lf is the average kinetic energy of the precursor ions, and (7 is the energy gained by post-dissociation acceleration. 

An alternative approach proposed by Musselman et al. utilizes a curved-field reflectron TOF analyzer as MS2. In their scheme, MSI would be scanned (when continuous ionization is used), while the curved-field reflectron TOF samples the 

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Some mass spectrometers combine several types of analysers. The most common ones include two or more of the following analysers electromagnetic with configurations EB or BE, quadrupoles (Q), ion traps (ITs) with Paul ion traps or linear ion traps (LITs), time-of-flight (TOF), ion cyclotron resonance (ICR) or orbitrap (OT). These are named hybrid instruments. The aim of a hybrid instrument is to combine the strengths of each analyser while avoiding the combination of their weaknesses. Thus, better performances are obtained with a hybrid instrument than with isolated analysers. Hybrids are symbolized by combinations of the abbreviations indicated in the order that the ions travel through the analysers. 

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