Hybrid compounds

Compounds 111 having structural features of the dual cyclooxygenase (COX)/5-lipooxygenase (5-LO) inhibitor tepoxalin and the 5-LO inhibitor ABT-761 were prepared. Many of these hybrid compounds are potent COX and 5-LO inhibitors two compounds (111, r =McO, R = R" = R = H, R = NH2, R = Me and r = MeO, R = R = Me, R" = R = H, R = Cl) inhibited eicosanoid biosynthesis in an ex vivo assay, but neither improved on the main deficiency of tepoxalin, duration of 5-LO inhibitory activity (99BMCL979). Compounds 111 inhibit the production of arachidonic acid products associated with 5-lipoxygenase and cyclooxygenase and are useful in the treatment of inflammatory disorders (99USP5925769). 

Hybrid compounds Nitric oxide-releasing agents ... 

The use of these spectral-reporter regions will be demonstrated for compound 10 and for the hybrid compound Gal(Man)5(GlcNAc)5. 

Various hybrid compounds comprised of two types of nitroxide radicals and either a pentamethine (Cy5) or trimethine cyanine (Cy3) were synthesized by Sato and co-workers [32]. These compounds seem to be promising fluorescent chemo-sensors for the measurement of reducing species such as Fe2+, ascorbic acid, and hydroxyl radicals. 

Sato S, Tsunoda M, Suzuki M, Kutsuna M, Takido-uchi K, Shindo M, Mizuguchi H, Obara H, Ohya H (2009) Synthesis and spectral properties of polymethine-cyanine dye-nitroxide radical hybrid compounds for use as fluorescence probes to monitor reducing species and radicals. Spectrochim Acta A 71 2030-2039... 

Fujii and coworkers reported the synthesis and detailed structural analyses of alkylammonium/magnesium phyllosilicate hybrids [88], which were prepared by hydrothermal reaction from a mixture ofoctadecyldimethyl(3-trimethoxysilylpropyl)-ammonium chloride, silica sol, and magnesium hydroxide Mg(OH)2. The structure of the hybrid compound was studied by XRD, TEM, electron diffraction, high-resolution solid-state NMR, TG-DTA/MS, and elemental analysis. The resulting analytical information confirmed the unit structure, which consists of a 2 1... 

Crystalline fructose, 23 485-486 Crystalline glycolic acid, 14 127 Crystalline hybrid compounds, 13 546-548 Crystalline inclusion compounds, 14 184 molecular recognition behavior of, 16 796 preparation of, 14 182 Crystalline melting point, of polymers, 20 399... 

Ng, Tang and Sederholm 66> also reported the solvent dependence of 2/F F in the sp3 hybridized compound CF2BrCFBr2 (Table 28). Again, the coupling constant increases and there is an apparent correlation between solvent polarity and the magnitude of the change. 

To assess, at least qualitatively, how much of the observed shift in the triphenylcarbonium ion is due to the change of hybridization from to sp and how much to the effect of the positive charge, a comparison of the chemical shifts of the triphenyl-C -carbonium and trimethyl-C -carbonium ions with their parent sp -hybridized covalent precursors and with some C -compounds having p -hybridization is useful. Data of Table 9, indicate that the C -shifts of ap -hybridized compounds (olefins and aromatic hydrocarbons), at least in the molecules studied (Lauterbur, 1957,1962), are very similar and fairly independent of the nature of the molecules. 

Hybrid compounds containing heterocyclic nitramine and em-dinitro functionality represent a class of high performance energetic materials. Such compounds frequently exhibit higher heats of formation, crystal density, detonation velocity and pressure, and better oxygen balance compared to analogous aromatic compounds. 

Bionolle is a typical biodegradable plastic. Currently, each raw material is made from petroleum, but we are developing more environmentally friendly green plastics. The first approach is to produce plastics from monomers such as succinic acid by biological methods. The second approach is to make hybrid compounds of Bionolle and natural resources like starch. The typical chain of materials for Bionolle is shown in Fig. 1. 

The hybrid compound of Bionolle and starch was developed by Showa Highpolymer in 2006 and has already been launched in the market. 

Honma, L. Y., Kuwahara, Y., Sato, M., Matsuyama, S. and Suzuki, T. (1995). Structurally hybridized compounds between the aggregation and alarm pheromones of mite triggering conflicted behavior of Carpoglyphus lactis. Journal of Pesticide Science 20 265-271. 

In the case of porphyrins different substitution patterns induce relevant electronic variations the energy level of the two HOMOs of the porphyrin n system (a/u and a2u) are in fact reversed in going from a meso-substituted porphyrin, such as tetraphenylporphyrin, to a -substituted one, such as octaethylporphyrin [44]. Electronic variations may also derive from conformational changes Smith and coworkers have reported hybrid compounds substituted both at meso and P positions, the Zn2+ complexes of 2,3,7,8,12,13,17,18-octaethyl- and 2,3,7,8,12,13,17,18-octamethyl-5,10,15,20-tetraphenylporphyrin [46] (see Sect. 3.3). These complexes have a nonplanar conformation caused by the steric interactions of the substituents. Theoretical calculations indicate that such conformational changes cause a differential shift in the energies of the HOMO and LUMO and so modulate the electronic structure of the macrocycles. 

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