Hyaluronic Acid-Liposome Formulations

Liposomes are stable nanocarriers which are used clinically to deliver therapeutic agents for various anticancer treatments. HA coated liposomes have also been developed which significantly improved the pharmacokinetics, biodistribution and circulation half-life in the blood. These liposomes are developed following either of the two different strategies. 

One of the oldest methods involves conjugation of HA oligosaccharide to phosphatidylethanolamine by reductive amination via the reducing end of HA. This amphiphilic HA is incorporated into the hilayer of the liposome by mixing with suitable lipid components like cholesterol, l-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine and so on, in different ratios. This HA-dioleoylphosphatidylethanolamine was 

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