Huntingtin protein

Gene is translated into huntingtin protein with abnormal glutamine repeats. 

Li SH, Li XJ (2004) Huntingtin-protein interactions and the pathogenesis of Huntington s disease. Trends Genet 20 146-154. 

Proteins with an expanded polyglutamine repeat are more resistant to proteasomal degradation [53]. Inhibition of the proteasome also induced accumulation of aggregated forms of a viral nucleoprotein reported by Anton et al. [54]. Recently was found an inhibition of the proteasome in a transfected cell line with a protein FLAG-F508 and with the Huntingtin protein [55]. 

Increased huntingtin protein length reduces the severity of poly-glutamine-induced gene expression changes in mouse models of Huntington Disease. Hum Mol Genet 11 1939-1951. 

Huntingtin bodies (Huntingtin protein) Mutations leading to increase in polyglutamine stretches (Q10-35 normal Q36-120 pathological) (Kagan et al. 2001 Ross 2002) Huntington s disease (neurons)... 

---