Oversulfated fucoidan

Teruya, T., Konishi, T., Uechi, S., Tamaki, H., and Tako, M. (2007). Anti-proliferative activity of oversulfated fucoidan from commercially cultured Cladosiphon okamuranus TOKIDA in U937 cells. Int. J. Biol. Macromol. 41, 221-226. 

Cationic chitosan was used to form a complex with oversulfated fucoidan (OFD), which is known to have antiangiogenic properties. The charge of the nanoparticles could be controlled by the ratio of both polyelectrolytes. It was found that at a pH of 6.5 the nanoparticles with a positive surface charge could open the tight junctions between Caco-2 cells, thereby allowing the transport of OFD, which is otherwise very poorly absorbed by the intestinal endothelium due to its high hydrophilicity. OFD could then inhibit the angiogenesis of human umbilical vein endothelial cells (HUVECs). 

Qiu, X Amarasekara, A Doctor, V. Effect of oversulfation on the chemical and biological properties of fucoidan. Carbohydrate Polymers, 2006, 63, 224-228. 

Soeda, S Ohmagari, Y Shlmeno, H Nagamatsu, A. Preparation of oversulfated fucoidan fragments and evaluation of their antithrombotic activities. Thrombosis Research, 1993, 72, 247-256. 

Koyanagi, S Tanigawa, N Nakagawa, H Soeda, S Shimeno, H. Oversulfation of fucoidan enhances its anti-angiogenic and antitumor activities. Biochemical Pharmacology, 2003, 65,173-179. 

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