Human salt bridge

Fig. 2. Salt bridges in human deoxyhemoglobin (6). For details of the stereochemistry see ref. 4.

Fig. 4. C-terminal salt bridges and the role of the residue F9j8 in the T and R structures of mammalian and fish hemoglobins, (a) Human T structure (b) human R structure (c) carp T structure (d) carp R structure. The letters F, G, and H denote helical segments FG, GH, and HC denote nonhelical segments. The same notation is used in Fig. 5 (23).

NAl/3 Val Val or Gly Ser Ac-Ala Ac-Ala In human and many other vertebrate deoxy-Hbs, the a-amino groups bind either organic phosphate or carbamino CO2, which in turn forms a salt bridge with Lys 82 of the same p chain in crocodile Hb, blocking of a-NHs or Pro in position 2 inhibits these functions... 

Figure 7-26 The allosteric effects of 2,3-bisphosphogly-cerate (BPG) bound to the (3 chains of human deoxyhemoglobin. The phosphate groups of the BPG form salt bridges with valines 1 and histidines 2 and 143 of both (3 chains and with lysine 82 of one chain. This binding pulls the A helix and residue 6 toward the E helix. From Amone.159...

Fig 12. Schematic diagram of the ferroxidase center of human rHF (a), and the equivalent region of horse light-chain ferritin (b) showing the ferroxidase site replaced by a salt bridge. 

---