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Human PXR

A variety of GEM models are now available in which aspects of mouse metabolism have been replaced by their human counterparts. Mice with knocked-out mouse pregnane X receptor (mPXR) and knocked-in human PXR (hPXR) have been available for some time. Now, mice with knocked-out mouse constitutive androstane receptor (mCAR) and knocked-in human CAR (hCAR) and mice with both hPXR and hCAR have been generated.63... [Pg.277]

Figure 4.6 (a) Amino acid sequence homology (% human receptor) between the DNA- and ligand-binding domains of PXR from different species [8]. (b) Amino acid differences in the ligand-binding domain of rat, mouse, and human PXR [48]. Circles designate positions where major shifts in the physical-chemical properties occur. [Pg.81]

Watkins RE, Maglich JM, Moore LB, Wisely GB, Noble SM, Davis-Searles PR, et al. 2.1 A crystal structure of human PXR in complex with the St. John s wort compound hyperforin. Biochemistry 2003 42 1430-8. [Pg.349]

Pollock, C. B., Rogatcheva, M. B., and Schook, L. B. (2007) Comparative genomics of xenobiotic metabolism a porcine-human PXR gene comparison. Mamm. Genome 18, 210-219. [Pg.145]

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See also in sourсe #XX -- [ Pg.3 , Pg.3 , Pg.244 ]



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PXR

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