Human milk nucleotides

It has been reported that IgG from fhe milk of healthy mothers has nucleotide-hydrolyzing activity that is not related to the activity of known enzymes (Semenov et ah, 2004). Human milk appears to contain a mixture of antibodies, some hydrolyzing ATP/AMP and others hydrolyzing only AMP (Semenov et ah, 2004). It has been suggested that these antibodies neutralize bacterial and viral DNA and RNA by forming complexes with them (Semenov et ah, 2004). Although these antibodies may play a protective role in breast milk and enhance the passive immunity of neonates, more research is needed to fully defermine their biological role (Semenov et ah, 2004). 

Semenov, D. V., Kanyshkova, T. G., Karotaeva, N. A., Krasnorutskii, M. A., Kuznetsova, I. A., Buneva, V. N., and Nevinsky, G. A. (2004). Catalytic nucleotide-hydrolyzing antibodies in milk and serum of clinically healthy human mothers. Med. Sci. Monit. 10, BR23-BR33. 

The chain lengths of all but three of the a-lactalbumins, considered in Section B, are 123 residues. One, rat a-lactalbumin, has a chain extension of 17 residues, giving 140 residues total. In their nucleotide sequence study Qasba and Safaya (1984) concluded that this extension arises from a T-to-G base change in the termination codon. Two sequences have fewer than 123 residues Rabbit has 122 residues and red-necked wallaby has 121 residues. The majority of the mammalian lysozymes (human, baboon, and equine milk rat urine and camel, pig 3, and langur stomach) have 130 residues. Bovine, caprine, and deer stomach lysozymes have 129 residues. Although pig stomach lysozyme 3 has 130 residues, two of its variants (1 and 2) have 128... 

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