Human glycolipid: sialyltransferase

Glycolipid Sialyltransferase Activities in Mouse and Human Tumor Cells... 

More recently, studies on Campylobacter jejuni have demonstrated how specific bacterial carbohydrate antigens can mimic the fine structure of human cell surface glycolipid structures and elicit autoimmune reactivity. Yuki et al.61 first identified that the lipooligosaccharide (LOS) of C. jejuni mimicked human G(M)1 ganglioside and subsequently extended these studies to demonstrate that specific single amino acid variants of the C. jejuni Cst-II sialyltransferase protein are responsible for the synthesis of LOS variants that in turn, mimic different... 

However, little is known about the expression of Lewis-x and sialyl-Lewis-x blood-group glycolipids with multilactosamine (or poly-lactosamine) chain-bound to ceramide. A novel sialyltransferase, SAT-3 (CMP-NeuAc nLcOse4Cer a2,3sia-lyltransferase Figure 1 Step 13), has been characterized in bovine spleen [147, 148], embryonic chicken brains [79, 130, 131], human colon carcinoma [79, 131, 132], melanoma WM266-4 cells [149], and human placenta [133]. 

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