Human Genome Diversity Project

Greely, H.T., "The Ethics of the Human Genome Diversity Project The North American Regional Committee s Proposal Model Ethical Protocol," in Human DNA Sampling Law and Policy—International and Comparative Perspectives. Kluwer Law Inti, pp. 239-256 (1997b). 

Human Genome Diversity Project, Summary Document (1994), available at http //www.stanford.edu/group/morrinst/hgdp/summary93.html. 

North American Regional Committee, Human Genome Diversity Project, "Proposed Model Ethical Protocol for Collecting DNA Samples," Hous. L. Rev., 33, 1431-1473 (1997). 

Diverse and focused approaches are likely to continue to provide complementary benefits. The portfolio of techniques will provide a more effective and comprehensive approach to the identification of an NCE for the number of drug targets being revealed through the Human Genome Mapping Project. 

The dimensionality of chemical structure space exceeds that of known biological functional space. The dimensionality of biological functional space has increased in recent years due to the discovery of a multitude of genes, largely from the Human Genome Project. This chapter, however, will focus on chemical diversity rather than functional diversity. Quantification of chemical diversity involves two areas first, the predefmition of a chemical space, accomplished by selection of a diversity metric and a compound representation (i.e., molecular descriptors) and second, a rational subset selection, or classification, method dependent on efficient dimensionality reduction. Here, we describe these methods, prerequisites for a definition... 

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