Human binding site

HairC are. Quaternary ammonium compounds are the active ingredients in hair conditioners (31—39,239). Quaternaries are highly substantive to human hair because the hair fiber has anionic binding sites at normal pH ranges. The use of quaternaries as hair conditioners can be broken down into creme rinses and shampoo conditioners. 

Sulfaphenazole (684) and sulfazamet (685) are both examples of relatively short acting sulfonamides (B-80MI40406) and their antibacterial activity has been tested against Escherichia coli, the former being more effective than the latter. Sulfaphenazole also displaces sulfonyl ureas from protein binding sites on human serum albumin and consequently increases the concentration of the free (active) drug and produces a more intense reaction that may result in hypoglycemia. 

Kallen, J., et al. Structure of human cyclophilin and its binding site for cyclosporin A determined by x-ray crystallography and NMR spectroscopy. Nature 353 276-279, 1991. 

The reactivity of the sodium pump isoforms toward ouabain can significantly differ between certain isoenzymes. The al-isoform from rat is reported to be 100-fold more resistant to ouabain than a2- or a3-isoform. In other species like rabbit, pig, dog or human these differences are not as distinct as in rat, due to a more sensitive al-isoform. At least two different types of ouabain binding sites are reported for the Na+/fC+-ATPase [1]. 

Recombinant soluble TNF-RI-IgGl fusion protein Etanercept, Enbrel is a chimeric molecule consisting of the extracellular domain of the TNF receptor I (TNF-RI) and the Fc portion of human IgGl. Two Fc domains are bound to each other via disulfide bonds, thereby yielding dimers with two binding sites for the TNF trimer. Etanercept binds with high affinity to extracellular TNF and reduces TNF activity. Etanercept is not effective in Crohn s disease, possibly because it does not lead to destiuction of membrane TNF-a expressing cells. Indications and side effects are similar to those of Infliximab and Adalimumab. 

Wu, B., Williams, G.T., Morimoto, R.I. (1987). Deletion of three protein binding sites in the serum-regulated promoter of the human gene encoding the 70 kDa heat shock protein. Proc Natl. Acad. Sci. USA 84, 2203-2207. 

Matthews DA, Smith WW, Ferre RA, Condon B, Budahazi G, Sisson W, Villafranca JE, Janson CA, McElroy HE, Gribskov CL et al (1994) Structure of human rhinovirus 3C protease reveals a trypsin-like polypeptide fold, RNA-binding site, and means for cleaving precursor polyprotein. CeU 77 761-771... 

Scholz B, Rechter S, Drach JC, Townsend LB, Bogner E (2003) Identification of the ATP-binding site in the terminase subunit pUL56 of human cytomegalovims. Nucleic Adds Res 31 1426-1433... 

Reddigari SR, Shibayama Y. Brunnee T. Kaplan AP Human Hageman factor (factor Xll) and high molecular weight kininogen compete for the same binding site on human umbihcal vein endothelial cells. J Biol Chem 1993 268 11982-11987. 

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