Human barrier analysis doing

These assumptions are fairly straightforward. There may be some question about the first one. Often the performance of others is judged as illogical, incomprehensible, and sometimes stupid. When the analyst begins to look at performance fiom the other s point of view and look at it in more depth, it is found to be logical and understandable. The HBA helps to discover these reasons. In order to do a human barrier analysis, the following are needed ... 

The trials described so far have commonly shown a lack of usefulness of NKi receptor antagonists in the treatment of pain. But we do not know whether the failure of the selected compounds is a matter of pharmacodynamics (e.g. poor penetration of the blood brain barrier) or a genuine discrepancy between animal and human pain pathophysiology (Urban and Fox, 2000). Hence, animal tests should carefully be chosen whether they are predictive or not, and it would be helpful if a wider range of conditions could be examined (Hill, 2000a). Therefore, new preclinical analysis methods should be developed for a more effective judgement of likely clinical outcomes. 

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