HPLC-MC-ICP

Van den Boom et al.150 have reported on the determination of silicon isotope ratio measurements in silicate materials by MC-ICP-MS (at a mass resolution of 2500 to resolve isobaric interferences) after sodium hydroxide sample digestion and purification of silicon. 829Si and 830Si have been determined for several silicon isotope standard reference materials. A precision for 830Si of 0.18-0.41 %o was achieved. Precise and accurate measurements of isotope ratios on transient signals by HPLC-MC-ICP-MS for nuclear application was performed by Giinther-Leopold et al.151... 

Nuclear fuel HPLC-MC-ICP-MS 238 Pu, 239 Pu, 240Pu,24 Pu 238Pu/239Pu Gunther-... 

Gas samples from fermenters Sb isotope ratios HPLC-MC- ICP-MS [81]... 

Measurement of Pu isotope ratios in nuclear fuel samples by HPLC—MC-ICP-MS. Int. J. Mass Spectrom., 242, 197—202. 

Santamaria-Femandez, R., Hearn, R., and Wolff, J.C. (2008) Detection of counterfeit tablets of an antiviral drug using delta S-34 measurements by MC-ICP-MS and confirmation by LA-MC-ICP-MS and HPLC-MC-ICP-MS. J. Anal. At. Spectrom., 23 (9), 1294-1299. 

Clough and co-workers reported on the uncertainty contribution using single and double isotopi-cally enriched spikes in the isotope dilution approach employing a multiple ion collector ICP-MS combined with an HPLC and with cold vapour generation (CV) to form HPLC-CV-MC-ICP-MS for the determination of MeHg in fish tissue.8 Two fish tissue reference materials DORM-2 (NRC, Canada) and BCR 464 were employed in these studies. The amount of each certified reference... 

Szpunar, J., Chassaigne, H., Donard, O.F.X., Bettmer,J. and Lobinski, R. (1997) Specia-tion of protein-bound cadmium in biological materials by size-exclusion and reversed-phase HPLC with ICP-MC detection. Spec. Publ. — Roy. Soc. Client., 202, 131-144. 

Santamaria-Femandez et al. investigated different approaches to identify such counterfeit products. First, they compared the discriminant power of approaches relying on S isotopic analysis for a large-scale investigation of a certain antiviral product [94]. They evaluated three different approaches dissolution of the samples followed by analysis by means of MC-ICP-MS, isolation of the API (active pharmaceutical ingredient) by high-performance liquid chromatography (HPLC)... 

Clough, R., Belt, S.T., Fairman, B., Catterick, T., and Evans, E.H. (2005) Uncertainty contributions to single and double isotope dilution mass spectrometry with HPLC-CV-MC-ICP-MS for the determination of methylmercury in fish tissue. J. Anal. 

HPLC has been coupled to the Neptune MC-ICP-MS, and a significant drift of the point-to-point isotope ratios during peak elution for the measurement of the uranium isotope ratio 235u/238u detected. To evaluate the reason for this drift, injections of the same sample via HPLC and via a flow injection system were compared. For both kinds of sample introduction, the drift in isotope ratio development during peak elution showed the same order of magnitude thus, chromatographic fractionation on the HPLC colunm was excluded as the major source. It was stated that the observed isotope ratio drift is supposedly due to an instrumental shift in mass bias over the peak width. °... 

---