Host-guest complementarity

Imposed Platonic / Archimedean solids icosidodecahedron (Fe o), icosahedron ( (Mo)Mo (]i) cuboctahedron (Mou), rhombicuboctabedron (O ) topological host-guest complementarity... 

The thermodynamic analyses described provide an important quantitative understanding of impurity incorporation from solution, namely, the factors affecting the separation can be broken into two parts related to (1) the relative liquid phase behavior of solute and impurities and (2) the relative solid-state host-guest complementarity. This can be more generally stated, as... 

Enantioselective recognition between chiral hosts and guests is of great interest. The required difference in stability between diastereoisomeric complexes often relies on three-point interactions between a well-preorganized receptor and the substrate. Hydrogen bonding as a directional interaction is of particular importance in this context, often in combination with steric host-guest complementarity. 

Fig. 3. Femchrome Fe complex as example from nature for lariat type complexon (left side), adjustment of steric and electronic host/guest complementarity in aW-homocalixarenes (right side).

The same velcrand has also been shown to engender cavitand-mediated endo-cytosis [188]. The authors demonstrated selective, controlled endocytosis of a trimethylammonium-tagged fluorescein to several types of living human cells with little observed cytotoxicity. This approach therefore represents a novel method of small-molecule trans-membrane transport controlled by host-guest complementarity. 

Fig. 6. a//-Homocalixarenes allow us to adjust the steric and electronic host/guest complementarity. 

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