Host-guest binding

Suckling, C. J., Host-guest binding by a simple detergent derivative tentacle molecules, J. Chem. Soc., Chem. Commun. (1982) 661-662. 

This technique does not require the equilibrium of the chemical system to be perturbed to measure the host-guest binding dynamics. Fluorescence correlation spectroscopy is based on the measurement of changes in the fluorescence intensity of individual molecules, which lead to intensity fluctuations.58 63 For this reason, the measurements are made by detecting the emission from a small sample volume (femtoliters to microliters) containing a small number of fluorophores. 

Corbett, P. T Otto, S. Sanders, J. K. M. Correlation between host-guest binding and host amplification in simulated dynamic combinatorial libraries. Chem. Eur.. 1. 2004,10, 3139-3143. 

Ludlow, R. R Liu, J. Li, H. Roberts, S. L. Sanders, J. K. M. Otto, S. Host-guest binding constants can be estimated directly from the product distributions of dynamic combinatorial libraries. Angew. Chem. Int. Ed. 2007, 46, 5762-5764. 

Scheme 1.2 Equilibria involved in redox-dependent host-guest binding.

NMR spectroscopy is a tremendously powerful tool for monitoring weaker host-guest binding processes. 

C. David Gutsche is retired from the position of Robert A. Welch Professor at Texas Christian University. He is a pioneer in the use of calixarenes in systems designed to mimic enzymes. He has prepared numerous calixarene-type molecules, evaluated their host-guest binding abilities, and studied their catalytic potentials [48,49],... 

For weak interactions as they occur in host-guest-binding it is important to realize a conceptual difference between the experimental value that is based on the weighted average ensemble of species and the merging of this ensemble into one more or less representative structure that is then commonly used in the delineation of interaction types between the binding partners. 

Estimating Solvent Contributions to Host-guest Binding... 

With the advent of modem instrumentation that furnish all pertinent thermodynamic data from a single experiment within a few hours calorimetry can help to tackle problems in host-guest binding that are inaccessible (principally or on a quantitative basis) to any other method. The power of enthalpic measurements, however, is unleashed only if put in a well-defined structural context. As a corollary, the benefit of sound structure-energy correlation on this basis calls for a more intense synthetic input. 

Host-Guest Binding as Seen from the Viewpoint... 

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