Hormones and related drugs

Hormones (and related molecules) are clearly regulated as drugs, and it appears that biological products are those which are made from the... 

As early as 1951, affinity chromatography was used for the separation of anti-hapten antibodies (Campbell et aL, 1951). Shortly afterwards, Lerman (1953) developed a similar method for purification of tyrosinase. The recent applications of affinity chromatography are too numerous to be detailed here, but broadly speaking, the method has been used for separation/purification of proteins, sugars and their derivatives, nucleic acids, nucleotides and their derivatives, amino acids and peptides, and various other systems that include thiols and disulfides (ligands-thiols or disulfides or organomercurial supports), steroidal hormones, coenzymes, vitamins, morphine and related drugs, antibiotics, protein receptors, and antibodies. 

Adrenoceptors interact not only with norepinephrine but also with the adrenal medullary hormone epinephrine and a number of chemically related drugs. However, the responses produced by the drugs in different autonomic structures differ quantitatively or qualitatively from one another. 

Is a controlled-release system required This question will primarily relate to systemic drug delivery applications, typically for potent drugs such as steroid sex hormones and, perhaps, peptides or peptidomimetic agents. 

Use of Hormones in Nonendocrine Disease. There are many examples of how various hormones and hormone-related drugs can be used to treat conditions that are not directly related to the endocrine system. For instance, certain forms of cancer respond to treatment with glucocorticoids (see Chapter 36). Drugs that block the cardiac beta-1 receptors may help control angina and hypertension by preventing excessive stimulation from adrenal medulla hormones (epinephrine, norepinephrine see Chapters 21 and 22). 

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