Hormone, systemic delivery

Codrons, V., et al. (2003) Systemic delivery of parathyroid hormone (1-34) using inhalation dry powders in rats. Journal of Pharmaceutical Sciences, 92 p. 938-950. 

The ability of certain metals to bind to estrogen receptor a suggests that these metals can increase the risk of disorders of the endocrine system (hormonal system, endocrine). Long exposure of women to lead and mercury can lead, among other things, to infertility, miscarriage, and premature delivery. 

An example of such a product is Sterile Medroxyprogestrone Acetate Suspension used for its contraceptive property. Such an injection is designed to provide up to three months of contraceptive activity. Another such product is a depot injection of leuprolode acetate, an analogue of gonadatropin-releasing hormone (see Drug delivery systems). In this case, the product is a sterilized powder of microspheres to be suspended upon the addition of an appropriate diluent and intended for monthly injection. 

Beck, L. R., and Pope, V. Z., Controlled-release delivery systems for hormones. Drugs, 270, 528, 1984. 

This compartment contains about one-third of total body water and is distributed between the plasma and interstitial compartments. The extracellular fluid is a delivery system. It brings to the cells nutrients (eg, glucose, fatty acids, amino acids), oxygen, various ions and trace minerals, and a variety of regulatory molecules (hormones) that coordinate the functions of widely separated cells. Extracellular fluid removes COj, waste... 

Sustained- and controlled-release devices for drug delivery in the vaginal and uterine areas are most often for the delivery of contraceptive steroid hormones. The advantages in administration by this route—prolonged release, minimal systemic side effects, and an increase in bioavailability—allow for less total drug than with an oral dose. First-pass metabolism that inactivates many steroid hormones can be avoided [183,184],... 

The Ca2+ -responsive conformationally changeable membrane may be a good model of a new drug-delivery system, where calcitonin or parathyloid hormone can be released for the homeostasis of serum Ca2+ level. 

---