Hormonal Stavudine

While this pattern of biochemistry does not exclude transient relapse of Graves hyperthyroidism (despite the finding of negative TSH receptor antibodies), or a transient thyroiditis, the authors speculated that indinavir (prescribed in this patient together with stavudine and lamivudine) had inhibited the glucuronidation of thyroxine and hence caused a rise in serum thyroid hormone concentrations. 

In a Swiss case-control study gynecomastia was associated with stavudine in 47 cases. Blood concentrations of luteinizing hormone were above the reference range in 40% of the cases and 29% had reduced testosterone concentrations (6). 

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