Modafinil hormonal

Drugs That Interfere with Hormonal Contraceptives Concomitant use of HIV-protease inhibitors, griseofulvin, modafinil, penicillins, rifampin, rifabutin, phenytoin, carbamazepine, or certain herbal supplements such as St. John s wort with hormonal contraceptive agents may reduce the effectiveness of the contraception and up to one month after discontinuation of these concomitant therapies. Therefore, women requiring treatment with one or more of these drugs must use two other effective or highly effective methods of contraception or abstain from heterosexual sexual contact while taking thalidomide... 

Brun et al. (216) evaluated the mental performance, hormone levels, and temperatures of eight sleep-deprived volunteers given 300-mg of modafinil at 22 00 and 08 00. Modafinil did not affect melatonin, cortisol, or growth hormone levels, but it did attenuate performance decrements, attenuate the nocturnal decrease in body temperature, and increase daytime body temperature. These temperature effects are different from what has been observed in non-sleep-deprived subjects. Bourdon et al. (217) found no effects of 200 mg of modafinil on thermal balance in neutral conditions and no effect on thermoregulation in cold conditions (despite a tendency toward greater reductions in core temperature when modafinil was applied in a cold environment). However, these authors did not examine temperature effects beyond 3 hr in the morning. The differences with... 

Bran J, Chamba G, Khalfallah Y, Girard P, Boissy I, Bastuji H, Sassolas G, Claustrat B. Effect of modafinil on plasma melatonin, corisol and growth hormone rhythms, rectal temperature and performance in healthy subjects during a 36 hour sleep deprivation. J Sleep Res 1998 7 105-114. 

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