Hormonal factors, in breast cancer

Collaborative Group on Hormonal Factors in Breast Cancer (1997) Breast cancer and hormone replacement therapy collaborative reanalysis of data from 51 epidemiological studies of 52,705 women with breast cancer and 108,411 women without breast cancer. Lancet 350 1047-1059... 

Collaborative Group on Hormone Factors in Breast Cancer 1996 Breast cancer and hormonal contraceptives collaborative reanalysis of individual data on 53 297 women with breast cancer and 100 239 women without breast cancer from 54 epidemiological studies. Lancet 347 1703, 1713... 

Collaborative Group on Hormonal Factors in Breast Cancer. Breast cancer and hormonal contraceptives Further results. Contraception 1996 54(suppl3) lS-106S. 

Hormone receptors also serve as prognostic factors in breast cancer. Patients with positive receptor levels tend to survive longer. 

The association between HER2 amplifi-cation/overexpression and poor clinical outcome suggests that HER2 has a key role in pathogenesis. An increasing body of evidence also supports the role of HER2 as an important predictive factor of response to chemotherapy and hormonal therapy in breast cancer (reviewed in [25-28]). 

Breast Cancer. Many studies have observed low incidences of hormone-dependent cancers, particularly breast cancer, in Asian countries compared with Western countries and it is becoming increasingly accepted that dietary factors play an important role. Although breast cancer can occur in either males or females, only about 1 % of all cases occur in men, and male breast cancer is a rare disease in all parts of the world." Although there appear to be some similar risk factors for breast cancer in males and females, there is no indication in the literature that diet is either a risk or a protective factor for male breast cancer. The development of breast cancer is known to be highly dependent on the hormones associated with female reproductive functions, while established genetic factors have been... 

Other host factors What other host factors may modify the carcinogenic response to ionizing radiation remains unclear, but it seems plain that hormonal factors, at least, play such a role in breast cancer. Immime competence and genetic characteristics, e.g., those governing DNA repair capabilities, are also possibilities. 

Sacchini V, Zurrida S, Andreoni G, Luini A, Galimberti V, Veronesi P, Intra M, Viale G, Veronesi U. Pathologic and biological prognostic factors of breast cancers in short- and long-term hormone replacement therapy users. Ann Surg Oncol 2002 9(3) 266-71. 

Ruohola, J.K., Valve, E.M., Karkkainen, M.J., Joukov, V., Alitalo, K., and Harkonen, P.L., Vascular endothelial growth factors are differentially regulated by steroid hormones and antiestrogens in breast cancer cells. Mol. Cell. Endocrinol., 149,29 0,1999. 

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