Hormesis supporting evidence

This chapter deals with correcting the use of conjectures as defaults in regulatory policy, in the context of experimental evidence of hormesis and causation and alternative probabilistic cancer models. Specifically, we summarize how the combination of mode-of-action and weight-of-evidence supports both J-shaped and U-shaped, rather than the linear, no-threshold (LNT) models. The EPA uses the terms nonlinear for the threshold model and low-dose-linear for the LNT models (meaning that the slope is greater than zero at zero dose), which is well-approximated by a straight line, at very low doses and beginning from zero dose (EPA 2005). 

Experimental data support the concept of radiation hormesis, and several review articles provide detailed evidence of this (Ren, 2006 Hoffman and Stempsev,... 

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