Homozygous beta thalassemia

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Rioya L, Grot R, Garabedian M, Cournot-Witmer G. Bone disease in children with homozygous beta thalassemia. Bone Miner 1990 8 69-86. 

A4. Aksoy, M., The first observation of homozygous hemoglobin S-alpha thalassemia and two types of sickle cell thalassemia disease (a) Sickle cell-alpha thalassemia disease, (b) sickle cell-beta thalassemia disease. Blood 22, 757-769 (1963). 

Beta-Thalassemia A disorder characterized by reduced synthesis of the beta chains of hemoglobin. There is retardation of hemoglobin A synthesis in the heterozygous form (thalassemia minor), which is asymptomatic, while in the homozygous form (thalassemia major, Cooley s anemia, Mediterranean anemia, erythroblastic anemia), which can result in severe compHcations and even death, hemoglobin A synthesis is absent. [NIH]... 

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