Homologous sequence

Although closed subshells differ fundamentally from closed shells, they do share some of their properties, in particular as regards the structure of excited configurations, and this allows comparisons between elements belonging to such sequences to be useful. An example will be found in 

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Zvelebil, M.J., et al. Prediction of protein secondary structure and active sites using the alignment of homologous sequences. /. Mol. Biol. 195 957-961, 1987. 

It follows from Fig. 9, that in a polymer homologous sequence, yield stress in filled melts is independent of molecular weight. 

Compare the DNA sequence to known protein sequences to verify exons, etc. with homologous sequences... 

The subsequent chain extension can be accomplished by the pedestrian step-by-step homologation sequence via the acyclic diyne 12 or by a more efficient block-to-block strategy. The step-by-step approach includes protiodesilylation of diyne 12 followed by coupling with the propargyl chloride 9 following the same protocol as for the preparation of 12 from 11 and subsequent repetitions of protiodesilylation and alkylation with chloride 9 to reach stages 16 and 18, respectively (Scheme 3). 

Homology screening. Using oligonucleotide probes based on known receptor sequences, search cDNA libraries for homologous sequences which may code for related receptors. The clones are then isolated and sequenced and used in expression studies to confirm the identity of the receptor. 

The specific information present in a PSSM, even when it is made from only two or three homologous sequences, particularly favors the similarity between the sequences aligned to compute it and can improve searching sensitivity dramatically. This is because constraints on each position in a multiple alignment become better defined as more exam-... 

Hein, J. (1989). A tree reconstruction method that simultaneously aligns and reconstructs ancestral sequences for any number of homologous sequences, when the phylogeny is given. Mol. Biol. Evol. 6, 649-668. 

Murzin, A. G. (1993). OB(oligonucleotide/oligosaccharide binding)-fold common structural and functional solution for non-homologous sequences. EMBO J. 12, 861-867. 

We design primers by aligning homologous sequences Ifom as many taxa as possible. These sequences can be readily retrieved from large sequence databases such as Genbank (http //www.ncbi.nlm.nih.gov/web/... 

Reactivity of pyrazino[2,3-3][l,3]thiazines was described in CHEC-II(1996) <1996CHEC-II(7)737>. The only recent report of reactions of this system, as summarized in Scheme 99 <2004CPB675>, describes N-protection followed by an ester reduction/homologation sequence. After further elaboration of the side chain, the ring nitrogen is deprotected by treatment with hydrochloric acid. 

Fig. 26. Nucleic acid structures. A The structure of the four bases in DNA, guanine (G), cytosine (C) adenine (A) and thymine (T). Uracil (U) replaces thymine (T) in RNA. B The spontaneous attraction of A for T and C for G allows the recognition of homologous sequences in aqueous solutions and the strong and specific hybridization of one sequence with its homologous sequence. C DNA forms a double helix at body temperature, which can be denatured to separate the strands by heating. D single stranded mRNA structure.

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