Homologous recombination, DNA

Kalev P, Simicek M, Vazquez I et al (2012) Loss of PPP2R2A inhibits homologous recombination DNA repair and predicts... 

Fanconi anemia Repair of double-strand breaks by homologous recombination DNA cross-linking agents, reactive oxidant chemicals Acute myeloid leukemia, squamous-ceU carcinomas Developmental abnormalities including infertility and deformities of the skeleton anemia... 

Herrero, A.B., Martm-Castellanos, C., Marco, E., Gago, F., Moreno, S., (2006). Crosstalk between nucleotide excision and homologous recombination DNA repair pathways in the mechanism of action of antitumor trabectedin. Cancer Res., 66(16), 8155-8162. 

A recombinant DNA molecule is a novel DNA sequence formed by in vitro combination of two non-homologous DNA molecules (or fragments) giving rise to genetic material. 

Homologous Two DNA sequences that are very similar or identical. Homologous recombination occurs between two genes that have very similar or identical sequences. Nonhomologous Two DNA sequences that are very different. Nonhomologous recombination can occur between two unrelated genes. 

Recombinant DNA technology has also facilitated detailed study of cytokine receptors. Based upon amino acid sequence homology, receptors are usually classified as belonging to one of six known superfamilies (Table 8.3). Individual members of any one superfamily characteristically display 20-50 per cent homology. Conserved amino acids normally occur in discrete bands or clusters, which usually correspond to a discrete domain in the receptor. Most receptors exhibit multiple domains. In some cases a single receptor may contain domains characteristic of two or more superfamilies. For example, the IL-6 receptor contains domains characteristic of both the haematopoietic and immunoglobulin superfamilies, making it a member of both. 

Soares DG Escargueil AE, Poindessous V, Sarasin A, de Gramont A, Bonatto D, Henriques JA, Larsen AK. (2007) Replication and homologous recombination repair regulate DNA double-strand break formation by the antitumor alkylator ecteinascidin 743. Proc Natl Acad Sci USA 104 13062-13067. 

---