Homogeneous solubilization

Homogeneous solubilization requires that the nucleophilic solid have some finite solubility (though low) in the organic phase and involves the dissolution of the inorganic salt in the organic phase, followed by ion exchange of the quat in the liquid phase with dissolved MY. The PT catalyst does not... 

There should be less than 50% difference in the incorporated Cy3 in both samples and Cy5 in both samples. There should be less than two times difference in the incorporation levels between the Cy3-labeled samples and the Cy5-labeled samples. If any of these criteria are not met, one should make sure that the starting amount of the protein is the same in both samples and repeat the labeling reaction after making sure that all the dye in the Cy3 and Cy5 tubes has been homogenously solubilized before Pansferring aliquots to the protein samples. 

Naik and Doraiswamy [206] reported that the homogeneous solubilization could be further subdivided into four types, models A to D, for the following reactions ... 

In contrast with the reaction mechanism of heterogeneous and homogeneous solubilization, Yufit et al. [208] proposed a new mechanism for SLPTC that included step-by-step formation of a cyclic ternary complex [208]. This mechanism is based on the formation of two pairs of binary complexes (BCs) and ternary complexes (TCs) obtained from the organic reactant RX, the solid reactant MY, and the PT catalyst QX adsorbed on a solid salt surface as follows [208] ... 

Because the concentration of the metal complex moiety in the polymer domain of a solid-state film is higher than that of a homogeneously solubilized complex in solution, even a simple spectrophotometer is effective for observing the gaseous molecule-binding reactions and ligand-bonding characteristics of complexes. 

Figure 19.5 Models for homogeneous solubilization (Naik and Doraiswamy, 1997)...

Table 19.3 Operating regimes of the four homogeneous solubilization SLPTC models shown in Figure 19.5... 

Figure 16.6 Model simulations for homogeneous solubilization (a) RX conversion (b) quat concentration in the organic phase. (Adapted from Naik, S.D. and Doraiswamy, L.K., AlChE J., 44, 612, 1998.)...

The variations in the composition of a biphasic mixture as a function of concentration and temperature have also revealed themselves in complex kinetic and (apparent) Arrhenius parameters. Examples of these effects are found in time-resolved studies of the dynamics of triplet excited state ketones [354, 355, 361, 362] and in kinetic studies of the allyl-p-dimethylamino-benzenesulphonate quaternization discussed above [357, 359, 363]. Prior to the development of a full understanding of the ramifications of phase separation phenomena, such complex behaviour was often misinterpreted and ascribed to the reaction of a homogeneously solubilized solute in the smectic phase [359, 361-363]. 

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