Homeostatic responses

KONG A N, YU R, CHEN c, MANDLEKAR s and PRIMIANO T (2000) Signal transduction events elicited by natural products role of M APK and caspase pathways in homeostatic response and induction of apoptosis . Arch Pharm Res, 23 1-16. 

Taken together, the homeostatic responses elicited by the initial decrease in plasma volume serve to decrease sodium filtration, increase sodium reabsorption, and, consequently, decrease sodium excretion in the urine. This conservation of sodium leads to conservation of water and an expansion of plasma volume toward normal. 

Increasing evidence indicates that a chronic opiate-induced upregulation of the cAMP pathway, manifested by increased concentrations of adenylyl cyclase, PKA and several phosphoprotein substrates for the protein kinase, contributes to opiate tolerance, dependence and withdrawal exhibited by locus ceruleus neurons [66]. This upregulated cAMP pathway can be viewed as a homeostatic response of the neurons to persistent opiate inhibition of the cells. In the chronic opiate-treated state, the upregulated cAMP pathway helps return neuronal firing rates to control levels, i.e. tolerance. Upon abrupt removal of the opiate via the administration of an opiate receptor antagonist, the upregulated cAMP accounts for part of the withdrawal activation of the cells. 

Diabetes is hypothesized to cause cardiac protein acetylation and the acetylation alters the protein function (Fig. 3b). Hypoxia-inducible factor-1 (HIFl) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. Diabetes interferes with cellular response to hypoxia. In hyperglycemic conditions HIFl degradation is increased because of enhanced HIFl acetylation by... 

Only the direct effects are indicated homeostatic responses to these direct actions may be important (see text). 

Table 7-3. Effects of Direct-Acting Cholinoceptor Stimulants. Only the Direct Effects Are Indicated Homeostatic Responses to These Direct Actions May Be Important (See Text). ...

Werner, J., Modeling homeostatic responses to heat and cold, Handbook of Physiology, edited by C. Blatteis and M. Fregly, Vol. Section 4 Adaptation to the Environment, Oxford University Press, Oxford, 1996, pp. 613-626. 

Overall, these data support the idea that cellular uptake of Mn is not a component in the regulation of cellular Mn concentrations. Thus there appears to be a poor homeostatic response of the rat to Mn deficiency with regard to intestinal, hepatic or extrahepatic cellular uptake of the element. An inability to compensate for a low dietary intake of Mn, or low tissue concentrations of Mn, by increased cellular uptake of the element, is consistent with the... 

McKinley MJ. CongiuM, Denton DA. P ukRG, Penschow J, Simpson JB, etal. The anterior wall of the third cerebral ventricle and homeostatic responses to dehydration. J Physiol 1984 79 421-427. 

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