Homeodomain-interacting protein kinase

Lan HC, Li HJ, Lin G, Lai PY, Chung BC (2007) Cyclic AMP stimulates SF-l-dependent CYPl lAl expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation. Mol Cell Biol 27 2027-2036... 

The homeodomain protein Pbxl was shown to interact with protein kinase A in the cyclic AMP-dependerrt regrrlation (at -250/-241) of the httman CYP17A1 gene [2144]. Frrrtheranalysis showed interaction at a cyclic AMP-related site (-80/-40) by SF-1 [2145]. Frrrther, interactions were shown for Spl and Sp3 (-227/-184) andNF-lC (-107/-85 and -178/-152) [2146]. SF-1 (vide supra) also interacts with p54 , NonO, and protein-associated splicing factor... 

These domains are often found as repeats in proteins that are involved in diverse biochemical processes. The LIM domains are thought to fimction as protein interaction modules, mediating specific contacts between members of functional complexes and modnlating the activity of some of the constituent proteins. Gronp 1 of the LIM proteins contain the LIM homeodomain (LHX), LIMK (LIM kinases) and LMO (rhombotin) subfamilies. 

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