Holick, Michael

Vitamin D Physiology, Molecular Biology, and Clinical Applications, edited by Michael F. Holick, 1999... 

For a review of the situation, an article by Jonathan V. Wright, M.D., in the May 2004 issue of the Townsend Letter for Doctors Patients spells out the role of vitamin D in preventing a number of illnesses. He argues that its insufficiency has resulted in a dramatic increase in these illnesses. It is titled Vitamin D Its Role in Autoimmune Diseases and Hypertension, and cites the work of Michael Holick, M.D., Ph.D., of Boston University. For our purposes, we note that the prevalence... 

Most people, though, are deficient in vitamin D. Michael Holick, M.D., Ph.D., director of the Vitamin D, Skin and Bone Research Laboratory at Boston University Medical Center and the author of the book The UV Advantage, considers vitamin D deficiency an unrecognized epidemic in both children and adults throughout the world. 

Figure 5 A schematic representation of various factors that regulate the metabolism of vitamin D to 1,25-dihydroxyvitamin D3. (Copyright Michael F Holick (2004) Vitamin D Importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. American Journai of Clinicai Nutrition 79 362-371, used with permission.)...

Figure 7 Photoproduction and sources of vitamin D. Vitamin D is metabolized in the liver to 25-hydroxyvitamin D [25(OH)D], which is responsible for maintaining calcium homeostasis. 25(OH)D is also converted to 1,25(OH>2 D in a variety of other cells and tissues for the purpose of regulating cell growth, immune function, as well as a variety of other physiologic processes that are important for the prevention of many chronic diseases. MS, multiple sclerosis RA, rheumatoid arthritis. (Copyright Michael F Holick (2004) Vitamin D Importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. American Journal of Clinical Nutrition 79 362-371, used with permission.)...

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