Holarrhena antidysenterica Apocynaceae

An alkaloid obtained from the seeds of Holarrhena antidysenterica (Apocynaceae). 

Other lupane natural products reported this year are lupa-5,20(29)-dien-3p-ol from Holarrhena antidysenterica (Apocynaceae),83 nepeticin (lup-20(29)-ene-3p,lla-diol) from Nepeta hindostana (Labiatae),84 3p-hydroxy lup-20(29)-en-30-al... 

Holarrhena antidysenterica (Apocynaceae), an Indian plant, is used for treatment of dysentery. The steroidal alkaloid conessine (101) was the main antiamebic constituent (Bonis and Schaeffer, 1992). The same compound occurs in Wrightia tomentosa. Another Indian plant, Chonemorpha fragrans (Apocynaceae), afforded the alkaloid chonemor-phine (102) which had an MIC of 25 p.g/ml in vitro (Bonis and Schaeffer, 1992). 

Apocynaceae Holarrhena floribunda Holarrhena antidysenterica Holaphyllamin Conessine... 

The stem bark of Holarrhena antidysenterica Wall. (Apocynaceae) yielded the known steroidal alkaloids holarrhimine, isoconessimine, and conimine (108). Leaves of Holarrhena curtisii King et Gamble yielded the known as well as new aminoglycosteroidal alkaloids holacurtine (102) and N-demethylholacurtine (103), respectively (109). 

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