Hoffmann, Friedrich

Hoffmann, Friedrich. 1738. Medicinae rationalis systematicae tomi quarti. Fratrkfurt/Main Francisci Varrentrapp. 

King, Lester. Medicine in 1695 Friedrich Hoffmann s FundamentaMedicinae. Bull Hist Med 43 (1969) 17-29. 

S. Uhlmann, U. Friedrichs,W. Eichler, S. Hoffmann, and P. Wiedemann, Direct measurement of VEGF-induced nitric oxide production by choroidal endothelial cells. Microvasc. Res. 62, 179-189 (2001). 

Zschocke J, Hoffmann GF (2004) Vademecum Metabolicum. Schattauer, Milupa, Friedrichs-dorf, pp 1-164... 

That s quite a claim for the little pill that was concocted in 1897 by Felix Hoffmann, a chemist working for the Bayer company in Germany. While Hoffmann did synthesize the first commercial sample of acetylsalicylic acid, as aspirin is known generically, he wasn t the first to produce the substance in the laboratory. That honor goes to Karl Friedrich Gerhardt, who, in 1853 at Montpellier University in France, concocted an impure version with an eye towards improving on the effects of salicylic acid, a commonly used painkiller. At the time salicylic acid was extracted from the leaves of the meadowsweet plant and used for the treatment of fevers and pain, particularly of the arthritic variety. But it had to be taken in... 

The theory of phlogiston did not appeal to all of Stahl s contemporaries. Notably is this true of two of the most popular chemistry teachers of the time, Hermann Boer-haave at Leyden and Friedrich Hoffmann of Berlin. Both of these men accepted the idea of Beclier s predecessors that combustion consisted in the loss of some substance, sulphur (sometimes called phlogiston by Hoffmann), oil (oleum) or pabulum ignis (the food of fire). by Boer-... 

Friedrich Hoffmann (1660-1742) as professor of medicine at Halle was influential in obtaining for Stahl his professorship in that university. His friendly relations with Stahl were, however, later disturbed by differences of opinion on scientific subjects. Hoffmann was a broadly trained scholar, a public-spirited and devoted officer of the university, a constant correspondent with eminent chemists of the time, and a member of several scientific societies. He was a widely known and highly respected physician, chemist and teacher, and published very many works and papers on medicine and chemistry. The latter were mainly on methods of analysis. Gmelin4 cites the titles of 122 books and papers pertaining to chemical analyses and descriptions of properties. Especially important were his treatises on mineral waters, and the salt contents of these, with methods for detecting the presence of the various constituents. He introduced the use of a mixture... 

Schulz, C., Becker, K., Friedrich, C., Helm, D., Hoffmann, K., Krause, C. and Seifert, B. (1999) The German Environmental Survey 1990/92 (GERES II) time-activity patterns of the general population in Germany. Epidemiology, 10, 200P. 

K. Hoffmann U. Resch-Genger Bundesanstalt fur Materialforschung und -prixfung, 12200 Berlin, Germany e-mail joerg.friedrich bam.de... 

Because the cause of CO poisoning which often resulted in death was unknown, myths emerged. Friedrich Hoffmann (1660-1742) of Halle, Germany, recounts that two farmers and a student used charcoal fire on a Christmas night the farmers died and the student was found very sick theologians, who claim to possess great knowledge, opined that it was a divine curse (Pankow, 2000). 

But unfortunately salicylic acid attacks the mucous membranes of the mouth and esophagus and causes gastric pain that may be worse than the discomfort it was meant to cure. Felix Hoffmann, a chemist for Friedrich Bayer, a German dye company, reasoned that the corrosive nature of salicylic acid could be altered by addition of an acetyl group and in 1893 the Bayer Company obtained a patent on acetylsalicylic acid, despite the fact that it had been synthesized some forty years previously by Charles Gerhardt. Bayer coined the name Aspirin for their new product to reflect its acetyl nature and its natural occurrence in the Spiraea plant. Over the years they have allowed the term aspirin to fall into the public domain so it is no longer capitalized. The manufacturers of Coke and Sanka work hard to prevent a similar fate befalling their products. 

Schulz C, Becker K, Friedrich C, Helm D, Hoffmann K, Krause C, Seifert B (1999) Epidemiol 10 200P... 

Ewers U, Krause C, Schulz C, Wilhelm M (1999) Int Arch Occup Environ Health 72 255 Friedrich C, Helm D, Becker K, Hoffmann K, Krause C, Nollke P, Schulz C, Seiwert M, Seifert B (2001) Umwelt-Survey 1990/92, BandVI,Hausstaub. Deskription derSpuren-element- und Biozidgehalte im Hausstaub der Bundesrepublik Deutschland. Umwelt-bundesamt, Berlin... 

If among the cast of characters our imaginary play had included Friedrich Hoffmann, what Freind has to say next could well have been addressed to him. Those indeed who pretend most to Mechanism, place this active Principle in the Aether, or some extremely subtil Fluid but then I wou d ask the Question, What is it, that actuates this Aether, and constantly preserves it in Motion How comes it to pass, that contrary Motions do not destroy one another And what is it, that determines these Motions, to produce such particular Effects, and no others These must necessarily be Occult Qualities residing in the Aether (pp. 190-191). What a clever ending. The Cartesians themselves can t get along without occult qualities even though they deny their existence. The curtain... 

Wang YS, Friedrichs U, Eichler W, Hoffmann S, Wiedemann P. Inhibitory effects of triamcinolone acetonide on bFGF-induced migration and tube formation in choroidal microvascular endothelial cells. Graefes Arch Clin Exp Ophthalmol 2002 240(1 ) 42—48. 

Van Melle, P.J. U.S.Patent 3.057JB51 Octobers, 1962 assigned to Armour-Pharmaceutical Bernhauer, K., Friedrich, W. and Zeller,P. U.S. Patent 3,120,509 February 4,1964 assigned to Hoffmann-La Roche Inc. 

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