Hodges design

The Original Hodges Design An 86-residue Analog of Tropomyosin (1981)... 

Flow chart showing the design of novel orally active HIV-1 protease inhibitor. (Figure adapted from Lam P K ]adhav, C E Eyermann, C N Hodge, Y Ru, L T Bacheler, ] L Meek, M ] Otto, M M Rayner, Y N V /ong, ang, P C Weber, D A Jackson, T R Sharpe and S Erickson-Viitanen 1994. Rational Design of Potent, able. Nonpeptide Cyclic Ureas as HIV Protease Inhibitors. Science 263 380-384.)... 

Lam PYS, Jadhav PK, Eyermann CJ, Hodge CN, Ru Y, Bacheler LT, Meek JL, Otto MJ, Rayner MM, Wong YN, Chang CH, Weber PC, Jackson DA, Sharpe TR, Erickson-Viitanen S. Rational design of potent, bioavailable, nonpeptide cyclic ureas as HIV protease inhibitors. Science 1994 263 380-4. 

Hodges RS. De novo design of alpha-heUcal proteins basic research to medical applications. Biochem Cell Biol 1996 74 133-154. 

Tripet, B., Wagschal, K., Lavigne, P., Mant, C. T., and Hodges, R. S. (2000). Effects of side-chain characteristics on stability and oligomerization state of a de novo-designed model coiled-coil 20 amino acid substitutions in position d. J. Mol. Biol. 300, 377-402. 

The designs by Hodges and colleagues in the section on heterodimeric coiled-coil systems (Chao et al, 1998 Litowski and Hodges, 2001, 2002), and by Ghosh et al (2000) in the next section, provide other examples of coiled-coil systems as potential peptide linkers. 

Hodges, R. S., Saund, A. K., Chong, P. C. S., Stpierre, S. A., and Reid, R. E. (1981). Synthetic model for 2-stranded alpha-helical coiled-coils - design, synthesis, and characterization of an 86-residue analog of tropomyosin. / Biol. Chem. 256, 1214-1224. 

Kohn, W. D., and Hodges, R. S. (1998). De novo design of alpha-helical coiled coils and bundles Models for the development of protein-design principles. Trends Biotech-nol. 16, 379-389. 

Litowski, J. R., and Hodges, R. S. (2001). Designing heterodimeric two-stranded alpha-helical coiled-coils The effect of chain length on protein folding, stability and specificity./. Pept. Res. 58, 477-492. 

Hodges and Raines (2003) carried out experiments for (4R)Flp and (4S)Flp in the X position using a (X-Y-Gly) 7 design, and reached similar conclusions to those seen for the ten repeating units. 

Lee, D.L., and Hodges, R.S. (2003) Structure-activity relationships of de novo designed cyclic antimicrobial peptides based on Gramicidin S. Biopolymers 71, 28—48. 

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