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Hit/lead generation

Bleicher KH, Bohm HJ, Muller K, Alanine AI. Hit and lead generation beyond high-throughput screening. Nat Rev Drug Discov 2003 2 369-78. [Pg.348]

A detailed screening pathway starting with a screen to generate hits and culminating in leads is also important for guiding lead generation efforts. An example is illustrated in Fig. 1. [Pg.182]

Alanine, A., Nettekoven, M., Roberts, E., and Thoma, A.W. Lead generation - enhancing the success of dmg discovery by investing in the hit to lead process. Comb. Chem. High Throughput Screen. 2003, 6, 51-66. [Pg.368]

Michne, W.F. Hit-to-lead chemistry a key element in new lead generation. Pharm. News 1996, 3, 19—21. [Pg.426]

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