Histology Langerhans cells

Vassallo R, Jensen EA, Colby TV, et al. The overlap between respiratory bronchiolitis and desquamative interstitial pneumonia in pulmonary Langerhans cell histiocytosis high-resolution CT, histologic, and functional correlations. Chest 2003 124(4) 1199-1205. 

The earliest histological feature is proliferation of Langerhans cells found around terminal and respiratory bronchioles (3,21). These early cellular lesions expand to form nodules that are typically 1 to 6 mm in diameter (21). These bronchiolo-centric nodules characteristically have a stellate configuration (Fig. la). The morphology of the nodules varies with the activity of the lesions. Early lesions are cellular. The peribronchiolar interstitium and adjacent alveolar septa are thickened by clusters of Langerhans cells admixed with variable numbers of eosinophils, neutrophils, lymphocytes, macrophages, and fibroblasts. Eosinophils are often numerous and can form eosinophilic abscesses but may be absent in up to 20% of... 

Vassallo R, Ryu JH, Schroeder DR, Decker PA, Limper AH (2002) Clinical outcomes of pulmonary Langerhans -cell histiocytosis in adults. N Engl J Med 346 484-490 Vassallo R, Jensen EA, Colby TV, Ryu JH, Douglas WW, Hartman TE et al (2003) The overlap between respiratory bronchiolitis and desquamative interstitial pneumonia in pulmonary Langerhans cell histiocytosis high-reso-lution CT, histologic, and functional correlations. Chest 124 1199-1205... 

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