Histology adipose tissue

The one-month farm swine studies evaluated safety following implantation of two doses of batimastat loaded on the 18 mm BiodivYsio stent in comparison to control stent without batimastat. Two batimastat doses were evaluated as described in Table 2. No deaths occurred during the implantation procedure and no sub-acute death or stent thrombosis was observed during the follow-up period. Histological examination confirmed that all the vessels were patent, without the presence of thrombus in the vessel lumen, All sections showed stent struts to be completely covered, leading to a smooth endoluminal surface. There was no excessive inflammatory response at stent struts in BiodivYsio-Batimastat-treated sections compared with the control sections. Medial and adventitial layers appeared similar in all three groups. The perivascular nerve fibers, the adipose tissue, and adjacent myocardium appeared normal in control and Biod/VV s/o-Batimastat-treated sections. Therefore, these studies demonstrated that the Biod/VY s/o Batimastat stent at CTD and >CTD was well tolerated up to 28 days. 

Figure 7.78 Histological haematoxylin/ eosin-stained tibia diaphysis peri-implant sections of rabbit, (a) Uncoated (group I), showing cancellous bone (1) and well-developed marrow spaces. Bone lamellae (2) are lined by osteoblasts. Marrow cavities contain adipose tissue (3). (b) Neo-formation of...

Figure 35.2 shows the histograms of adipose cell size obtained from the untreated control and thiamine-treated 55-week-old rats. Histological evaluation revealed that smaller adipocytes in epididymal white adipose tissues were predominant in the thiamine-treated group compared with the untreated control group. 

Figure 2.17 Representative histological sections of scaffolds implanted in femoral condyle defects (a and b) a PPF scaffold 4 weeks after implantation, (c and d) a US-tube-PPF scaffold after 4 weeks, (e andf) a PPF scaffold after 12 weeks, and (g and h) a US-tube-PPF scaffold after 12weeks implantation. The images are presented at 1.6A and 10A magnification. The PPF scaffold (P) appears as white areas in all images. The original defect edge (DE) is visible in the low-magnification images. Bone-like tissue (BT) appears red direct bone implant contact (BIC) occurred with the US-tube-PPF nanocomposite scaffold 12 weeks after implantation. US tubes (UST), connective tissue (CT), adipose cells (AC), and inflammatory cells (IC) are also shown. Adapted from Sitharaman B, Shi X, Walboomers XF, Liao H, Cuijpers V, Wilson LJ, et al.

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